Breast Biopsy Study: How Many Samples Are Enough?
Author Information
Author(s): G Sauer, H Deissler, K Strunz, G Helms, E Remmel, K Koretz, R Terinde, R Kreienberg
Primary Institution: University of Ulm Medical School
Hypothesis
How many large-core needle biopsies are needed for reliable tumor classification of breast lesions?
Conclusion
Three 3D ultrasound-guided core samples are sufficient for a reliable histological assessment of breast lesions.
Supporting Evidence
- 98.2% sensitivity for diagnosing breast malignancies with three cores.
- Only 3.9% false-negative rate in identifying malignancies.
- 75.9% of cases required only two biopsies for a clear diagnosis.
Takeaway
Doctors can use just three needle samples to check for breast cancer instead of more, making the process easier for patients.
Methodology
The study analyzed 962 breast lesions using 3D ultrasound-guided large-core needle biopsies over 28 months.
Potential Biases
Potential bias due to the single-institution study design and operator experience.
Limitations
The study was conducted at a single institution, which may limit generalizability.
Participant Demographics
906 patients with breast lesions, both palpable and nonpalpable.
Statistical Information
P-Value
0.001
Statistical Significance
p=0.001
Digital Object Identifier (DOI)
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