Preventing Diabetes in Mice with Nicotinamide and Soy Protein
Author Information
Author(s): S. REDDY, M. KARANAM, E. ROBINSON
Primary Institution: University of Auckland
Hypothesis
Can oral nicotinamide or a soy protein-based infant formula prevent cyclophosphamide-induced diabetes in NOD mice?
Conclusion
Oral nicotinamide or Prosobee, either alone or together, prevents cyclophosphamide-induced diabetes in NOD mice.
Supporting Evidence
- NOD mice given cyclophosphamide developed diabetes at a rate of 63%, while those given nicotinamide or Prosobee did not develop diabetes.
- Insulitis scores were significantly lower in mice treated with nicotinamide or Prosobee compared to those on a standard diet.
- Oral nicotinamide and Prosobee reduced the expression of inducible nitric oxide synthase in islets.
Takeaway
Giving special diets to mice can stop them from getting diabetes caused by a certain drug.
Methodology
NOD mice were divided into five groups and given different diets, with some receiving cyclophosphamide to induce diabetes, while others received nicotinamide or Prosobee.
Limitations
The study was conducted on mice, and results may not directly translate to humans.
Participant Demographics
Female NOD mice were used in the study.
Statistical Information
P-Value
0.03
Statistical Significance
p=0.03
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