Modulating delirium through stimulation (MoDeSt): study protocol for a randomized, double-blind, sham-controlled trial assessing the effect of postoperative transcranial electrical stimulation on delirium incidence
2025

Study Protocol for Preventing Delirium in Elderly Patients Using Electrical Stimulation

Sample size: 225 publication Evidence: moderate

Author Information

Author(s): Sophie Leroy, Viktor Bublitz, Ulrike Grittner, Robert Fleischmann, Falk von Dincklage, Daria Antonenko

Primary Institution: Universitätsmedizin Greifswald

Hypothesis

Does postoperative transcranial electrical stimulation reduce the incidence of postoperative delirium in elderly patients undergoing major surgery?

Conclusion

Transcranial electrical stimulation may be an effective method to prevent postoperative delirium in elderly patients.

Supporting Evidence

  • Postoperative delirium is common in elderly patients and can lead to serious complications.
  • Transcranial electrical stimulation has shown promise in modulating brain activity.
  • The study aims to evaluate the effectiveness of tES in preventing POD.

Takeaway

This study is trying to see if a special type of brain stimulation can help older people not get confused after surgery.

Methodology

A randomized, double-blind, sham-controlled trial with three groups receiving different types of electrical stimulation.

Potential Biases

Potential biases may arise from the single-center design and participant selection.

Limitations

The study is limited to a single center and may not generalize to all populations.

Participant Demographics

Patients over 65 years undergoing elective major surgery.

Digital Object Identifier (DOI)

10.1186/s13063-024-08699-1

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