Structural Changes in the Multifidus Muscle Due to Intervertebral Disc Degeneration
Author Information
Author(s): Wang Yaobin, Zhao Xinghua, Zhang Xiangyu, Yang Yuhua, Zhang Weikang, Liu Shaocheng, Liu Zhenlei, Zhang Lei, Wang Kai, Wu Hao
Primary Institution: Xuanwu Hospital, Capital Medical University, Beijing, China
Hypothesis
This systematic review aims to evaluate the structural changes in paraspinal muscles, particularly the multifidus, in animal models of intervertebral disc degeneration.
Conclusion
The review provides insights into the structural changes in the multifidus muscle associated with intervertebral disc degeneration, highlighting the need for improved animal models.
Supporting Evidence
- The review included nine studies that assessed structural changes in the multifidus muscle due to intervertebral disc degeneration.
- Significant reductions in multifidus muscle mass were observed in some studies after intervertebral disc injury.
- Fat infiltration in the multifidus muscle was consistently reported across multiple studies.
- Changes in muscle fiber type composition were noted, with a decrease in type I fibers in degenerative conditions.
Takeaway
This study looked at how the muscles in the back change when the discs in the spine get damaged, helping us understand back pain better.
Methodology
A systematic review of studies was conducted by searching multiple databases and applying strict inclusion and exclusion criteria.
Potential Biases
The majority of studies had unclear risks of bias due to inadequate reporting on randomization and blinding.
Limitations
The limited number of studies and substantial heterogeneity among them prevented a quantitative meta-analysis.
Participant Demographics
The studies included various animal models, primarily rodents and sheep, without specific demographic details.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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