Down-Regulation of NDRG1 Promotes Migration of Cancer Cells during Reoxygenation
2011
NDRG1 and Cancer Cell Migration during Reoxygenation
publication
Evidence: moderate
Author Information
Author(s): Lai Liang-Chuan, Su Yi-Yu, Chen Kuo-Chih, Tsai Mong-Hsun, Sher Yuh-Pyng, Lu Tzu-Pin, Lee Chien-Yueh, Chuang Eric Y.
Primary Institution: National Taiwan University
Hypothesis
Does down-regulation of NDRG1 promote migration of cancer cells during reoxygenation?
Conclusion
The study found that down-regulation of NDRG1 significantly promotes the migration of breast cancer cells during reoxygenation.
Supporting Evidence
- 127 differentially expressed genes were identified during reoxygenation.
- NDRG1 was significantly down-regulated upon reoxygenation.
- Overexpression of NDRG1 inhibited cell migration in MCF-7 cells.
Takeaway
When cancer cells get more oxygen after being starved of it, they can move around more easily if a certain protein called NDRG1 is turned down.
Methodology
Breast cancer MCF-7 cells were cultured under hypoxia followed by reoxygenation, and gene expression was analyzed using microarrays.
Statistical Information
P-Value
<0.0001
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website