Effects of Advanced Glycation End Products on Stem Cells

publication Evidence: moderate

Author Information

Author(s): Zheng Zetai, Zhou Hui, Zhang Wenwen, Wang Tingyu, Swamiappan Sathiskumar, Peng Xinsheng, Zhou Yanfang

Primary Institution: Guangdong Medical University, Dongguan, China

How do advanced glycation end products (AGEs) affect the physiological functions of stem cells?

AGEs negatively impact the physiological functions of stem cells, which could hinder their therapeutic applications in regenerative medicine.

AGEs can create an environment that is detrimental to the normal physiological functions of stem cells.
AGEs disrupt the physiological activities of stem cells by binding to the receptor for advanced glycation end products (RAGE).
AGEs significantly impair cell adhesion within the extracellular matrix, increasing cellular sensitivity to apoptosis.
AGEs contribute to apoptosis and senescence in stem cells through the activation of signaling pathways.

AGEs are bad for stem cells because they can make them sick and stop them from working properly, which is important for healing.

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