VEGF-C in Colorectal Cancer
Author Information
Author(s): Akagi K, Ikeda Y, Miyazaki M, Abe T, Kinoshita J, Maehara Y, Sugimachi K
Primary Institution: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
Hypothesis
What is the relationship between VEGF-C expression and clinicopathological features in colorectal cancer patients?
Conclusion
VEGF-C may play an important role in the lymphatic spread of colorectal cancer.
Supporting Evidence
- VEGF-C expression correlated with lymphatic involvement and lymph node metastasis.
- There was no correlation with gender, histologic type, venous involvement, or liver metastasis.
- Survival time was shorter for VEGF-C positive groups compared to negative ones.
Takeaway
VEGF-C is a protein that helps cancer spread through the lymphatic system, and its presence in tumors can indicate how aggressive the cancer is.
Methodology
The study examined VEGF-C expression in 99 primary tumors and 18 metastatic lymph nodes using immunohistochemistry and RT-PCR.
Limitations
Survival time differences were not statistically significant.
Participant Demographics
Patients with colorectal cancer.
Digital Object Identifier (DOI)
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