Modeling the effect of PTPN22 in rheumatoid arthritis
Author Information
Author(s): Bourgey Mathieu, Perdry Hervé, Clerget-Darpoux Françoise
Primary Institution: INSERM U535, Université Paris-Sud
Hypothesis
How do specific SNPs in the PTPN22 gene affect the risk of developing rheumatoid arthritis?
Conclusion
The study found that the combined effect of three SNPs in the PTPN22 gene significantly increases the risk of rheumatoid arthritis.
Supporting Evidence
- The study identified three SNPs that significantly increase the risk of rheumatoid arthritis.
- Genotypic relative risks varied from 1 to 4.7 when considering multiple SNPs.
- IBD sharing patterns were consistent with the defined risk genotypic classes.
Takeaway
This study shows that certain genetic changes can make people much more likely to get rheumatoid arthritis.
Methodology
The study analyzed SNPs in families with affected siblings and unrelated controls to estimate genetic risks and associations.
Limitations
The study may not account for all genetic factors influencing rheumatoid arthritis risk.
Participant Demographics
511 families with affected sib pairs and 1404 unrelated controls.
Statistical Information
P-Value
p = 0.005
Statistical Significance
p<0.05
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