Syndecan-1 and Head and Neck Cancer Prognosis
Author Information
Author(s): Anttonen A, Kajanti M, Heikkilä P, Jalkanen M, Joensuu H
Primary Institution: Helsinki University Central Hospital
Hypothesis
The expression of syndecan-1 has prognostic significance in squamous cell carcinoma of the head and neck.
Conclusion
Syndecan-1 is a novel prognostic factor in head and neck squamous cell carcinoma treated with surgery and post-operative radiotherapy.
Supporting Evidence
- Low syndecan-1 expression was linked to low histological grade of differentiation.
- A low number of syndecan-1-positive tumor cells was associated with larger tumor size.
- Positive nodal status correlated with low syndecan-1 expression.
- Low syndecan-1 expression was associated with higher clinical stage.
- Unfavorable overall survival was linked to low syndecan-1 expression in univariate analysis.
- Clinical stage and syndecan-1 expression were independent prognostic factors in multivariate analysis.
Takeaway
Syndecan-1 helps doctors understand how serious a patient's head and neck cancer might be based on its expression.
Methodology
Immunohistochemistry was used to study syndecan-1 expression in paraffin-embedded tissue samples from patients.
Participant Demographics
Patients with primary squamous cell carcinoma of the head and neck.
Statistical Information
P-Value
P < 0.0001, P = 0.02, P = 0.0006, P = 0.001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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