Combined Treatment of Heterocyclic Analogues and Benznidazole upon Trypanosoma cruzi In Vivo
Author Information
Author(s): Batista Denise da Gama Jaén, Batista Marcos Meuser, de Oliveira Gabriel Melo, Britto Constança Carvalho, Rodrigues Ana Carolina Mondaine, Stephens Chad E., Boykin David W., Soeiro Maria de Nazaré Correia
Primary Institution: Fundação Oswaldo Cruz-Instituto Oswaldo Cruz, Rio de Janeiro, Brazil
Hypothesis
Can the combination of benznidazole with diamidine prodrug DB289 and arylimidamide DB766 enhance treatment efficacy against Trypanosoma cruzi infection?
Conclusion
The combination of DB289 and benznidazole significantly reduced parasitemia and protected against mortality in mice infected with Trypanosoma cruzi.
Supporting Evidence
- DB289 alone reduced parasitemia by about 70%.
- Benznidazole alone reduced parasitemia by about 90%.
- The combination of DB289 and Benznidazole decreased parasitemia by 99%.
- DB766 combined with Benznidazole provided 100% protection against mortality.
- DB766 alone reduced parasitemia by 96%.
Takeaway
Researchers found that using two different medicines together can help sick mice get better from a parasite that causes Chagas disease.
Methodology
Mice infected with Trypanosoma cruzi were treated with DB289 and benznidazole, and their parasitemia and survival rates were monitored.
Limitations
The study did not achieve a complete parasitological cure in any treatment group.
Participant Demographics
Male Swiss mice, 20-24 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website