Effects of Rauscher Murine Leukaemia Virus on Tumor Immunity in Mice
Author Information
Author(s): A.C. Knulst, D. Berends, C. Bazuin, H.C.J. van Rooij, N.J. de Both, R. Benner
Primary Institution: Erasmus University
Hypothesis
Can Rauscher murine leukaemia virus-induced tumor cells induce delayed-type hypersensitivity (DTH) in mice?
Conclusion
Rauscher murine leukaemia virus-induced tumor cells can induce a T-cell dependent DTH response in syngeneic mice.
Supporting Evidence
- RMB-1 cells induced a pronounced DTH response.
- Cross-reactivity was found among the R-MuLV-induced tumor cell lines.
- IFN-y treatment increased the DTH response.
- Suppression of DTH was observed after i.v. pre-immunization with irradiated tumor cells.
Takeaway
The study shows that certain cancer cells can make the immune system react, helping to fight the cancer.
Methodology
Mice were immunized with irradiated tumor cells and DTH responses were measured by foot thickness increase.
Limitations
The responses from some tumor cell lines were not significant above background levels.
Participant Demographics
Female BALB/c and DBA/2 mice, 4 weeks of age.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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