Impact of Maternal Lipid Profiles on Fetal Heart Function
Author Information
Author(s): Belovan Biliana, Popa Zoran Laurentiu, Citu Cosmin, Citu Ioana Mihaela, Sas Ioan, Ratiu Adrian, Varrassi Giustino
Primary Institution: Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
Hypothesis
Maternal dyslipidemia is associated with altered fetal cardiac function parameters.
Conclusion
Elevated maternal triglyceride levels and BMI are linked to poorer fetal cardiac function at mid-gestation.
Supporting Evidence
- Maternal BMI was significantly higher in the dyslipidemia group compared to the control group.
- Fetal echocardiographic measurements indicated reduced global longitudinal strain in fetuses of mothers with high triglycerides.
- Significant correlations were found between maternal triglyceride levels and fetal LV strain.
- Regression analysis identified maternal triglyceride levels and BMI as significant predictors of reduced fetal LV strain.
Takeaway
Moms with high fat levels in their blood can affect their baby's heart health while they're still in the belly.
Methodology
This was a prospective cohort study involving 76 pregnant women, divided into two groups based on triglyceride levels, with echocardiographic assessments of fetal cardiac function.
Potential Biases
Potential confounders may have influenced the results despite adjustments.
Limitations
The study's small sample size limits its statistical power and generalizability.
Participant Demographics
Pregnant women aged 27–40 years with singleton pregnancies.
Statistical Information
P-Value
p < 0.001 for triglyceride levels and fetal cardiac function.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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