Measuring Lansoprazole in Liquid Formulations
Author Information
Author(s): Stacy D. Brown, Justin D. Connor, Nicholas C. Smallwood, Ralph A. Lugo
Primary Institution: East Tennessee State University
Hypothesis
The study aims to develop and validate a method for quantifying lansoprazole in oral suspension using advanced chromatography and mass spectrometry techniques.
Conclusion
The developed method effectively quantifies lansoprazole in oral suspension and indicates that its stability is compromised after 72 hours at room temperature.
Supporting Evidence
- The method achieved a limit of detection of 2 ng/mL for lansoprazole.
- Calibration curves were linear with R2 values ranging from 0.9972 to 0.9991.
- The method demonstrated high precision with intraday and interday coefficients of variation below 10%.
Takeaway
This study created a way to measure a medicine called lansoprazole in a liquid form, showing that it doesn't stay good for very long if not kept cold.
Methodology
The study used ultra-high-performance liquid chromatography coupled with hybrid ion-trap time-of-flight mass spectrometry to quantify lansoprazole in a 3 mg/mL oral suspension.
Limitations
The study primarily focused on a single formulation and did not explore other concentrations or formulations of lansoprazole.
Digital Object Identifier (DOI)
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