Study of Organotin Complexes with Schiff Bases from Sulpha Drugs
Author Information
Author(s): M. K. Gupta, Har Lal Singh, S. Varshney, A.K. Varshney
Primary Institution: Department of Chemistry, University of Rajasthan, Jaipur, India
Hypothesis
The study aims to synthesize and characterize organotin(IV) complexes derived from Schiff bases of sulpha drugs and evaluate their antimicrobial activities.
Conclusion
The synthesized organotin complexes showed significant antimicrobial activity, particularly against certain fungi.
Supporting Evidence
- All synthesized complexes were found to be active against gram-positive bacteria.
- Complexes with hydroxy naphthalene nucleus showed higher activity than those with salicylaldehyde or hydroxyacetophenone.
- Tin complexes exhibited greater antimicrobial activity compared to the ligands alone.
- The activity was notably high against Penicillium chrysogenum, Aspergillus niger, and Fusarium oxysporum.
Takeaway
Scientists made new compounds using tin and special chemicals from sulpha drugs, and these new compounds can help fight germs and fungi.
Methodology
The study involved synthesizing organotin(IV) complexes, characterizing them using various spectroscopic methods, and testing their antimicrobial activities in vitro.
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