Oxidative Stress and Antioxidant Defense in Chronic Hepatitis C Patients
Author Information
Author(s): Levent Görenek, Ali Acar, Ahmet Aydın, Polat Eyigun Can, Aytaç Çetinkaya, Ayşe Eken, Ahmet Sayal
Primary Institution: Gülhane Military Medical Academy
Hypothesis
The study aims to determine the oxidant/antioxidant status of patients with chronic hepatitis C and the effect of pegylated interferon alfa-2b plus ribavirin therapy on oxidative stress.
Conclusion
Chronic hepatitis C patients experience oxidative stress, but this can be mitigated by pegylated interferon alfa-2b plus ribavirin therapy.
Supporting Evidence
- Serum MDA levels increased significantly in CHC patients before treatment compared to healthy subjects.
- MDA concentration decreased significantly after treatment.
- Antioxidant enzyme levels were significantly lower in CHC patients before treatment.
Takeaway
People with chronic hepatitis C have too much stress in their bodies from bad stuff called oxidants, but a special medicine can help fix that.
Methodology
Nineteen patients with chronic HCV infection and 28 healthy controls were studied, measuring various serum and erythrocyte parameters before and after treatment.
Limitations
The study had a small sample size and was limited to a single treatment regimen.
Participant Demographics
Nineteen patients (11 males, 8 females) with a mean age of 38 years and 28 healthy controls (18 males, 10 females) with a mean age of 26.67 years.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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