Comparing Subcoronary and Supracoronary Aortic Stenosis in Pigs
Author Information
Author(s): Mette Sorensen, J Michael Hasenkam, Henrik Jensen, Erik Sloth
Primary Institution: Aarhus University Hospital
Hypothesis
Can subcoronary aortic banding create a human-compatible model for valvular aortic stenosis?
Conclusion
Both subcoronary and supracoronary aortic banding induce similar levels of left ventricular hypertrophy in pigs.
Supporting Evidence
- Subcoronary and supracoronary banding both resulted in increased left ventricular wall thickness compared to controls.
- The heart/body weight ratio was significantly higher in both intervention groups compared to the control group.
- No significant differences were found in coronary blood flow ratios between the two intervention groups.
Takeaway
The study shows that two different ways of narrowing the aorta in pigs can make their hearts grow bigger, which helps scientists understand heart problems better.
Methodology
The study involved 20 kg pigs undergoing subcoronary or supracoronary aortic banding or a sham operation, with follow-up echocardiography and measurements of heart and blood flow.
Potential Biases
The study's design may have introduced bias due to the complexity of the surgical procedure and the small number of animals.
Limitations
The study had a small sample size and high mortality in the subcoronary group, which may affect the results.
Participant Demographics
Female Danish Landrace pigs, approximately 20 kg.
Statistical Information
P-Value
0.0055
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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