Specific oncolytic activity of herpesvirus saimiri in pancreatic cancer cells
2000
Herpesvirus Saimiri and Pancreatic Cancer
publication
Author Information
Author(s): Stevenson A J, Giles M S, Hall K T, Goodwin D J, Calderwood M A, Markham A F, Whitehouse A
Primary Institution: Molecular Medicine Unit, University of Leeds, St. James’s University Hospital, Leeds, LS9 7TF, UK
Hypothesis
Can herpesvirus saimiri selectively lyse pancreatic cancer cells?
Conclusion
Herpesvirus saimiri may be a potential oncolytic agent for treating pancreatic cancer.
Supporting Evidence
- The pancreatic cancer lines MIAPACA and PANC-1 showed cytopathic effects when infected with the virus.
- Colonic carcinoma cell lines SW480 and HCT116 were not affected by the virus.
- Virus recovery assays indicated minimal virus replication after one week in culture.
Takeaway
This study found that a virus can kill pancreatic cancer cells but not other types of cancer cells.
Methodology
The study investigated the effects of herpesvirus saimiri on various human cancer cell lines.
Digital Object Identifier (DOI)
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