Association of PTPN22 1858 SNP with Rheumatoid Arthritis in German Patients
Author Information
Author(s): Pierer Matthias, Kaltenhäuser Sylke, Arnold Sybille, Wahle Matthias, Baerwald Christoph, Häntzschel Holm, Wagner Ulf
Primary Institution: University of Leipzig
Hypothesis
The PTPN22 1858T allele is associated with an increased risk of developing rheumatoid arthritis (RA) in a German cohort.
Conclusion
The PTPN22 1858T allele is significantly associated with rheumatoid arthritis, particularly in male patients.
Supporting Evidence
- The odds ratio for developing RA was 2.57 for carriers of the PTPN22 1858T allele.
- The frequency of the PTPN22 1858T allele was significantly higher in male patients (53.8%) compared to female patients (33.0%).
- The PTPN22 1858T allele was associated with both RF positive and RF negative RA.
- Homozygous carriers of the PTPN22 1858T allele had an odds ratio of 5.58 for developing RA.
Takeaway
This study found that a specific gene variant is more common in men with rheumatoid arthritis, suggesting that genetics play a big role in the disease.
Methodology
Genotyping of the PTPN22 1858 SNP was performed using a PCR-based genotyping assay on DNA from 390 RA patients and 349 controls.
Potential Biases
Potential sample bias due to the recruitment of patients from a single center.
Limitations
The study population was ethnically homogenous, which may limit the generalizability of the findings.
Participant Demographics
The cohort consisted of 390 RA patients (76.1% female) and 349 healthy controls (63.6% female), all of German origin.
Statistical Information
P-Value
p < 0.001
Confidence Interval
95% CI 1.85–3.58
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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