S100A6 Expression in Colorectal Cancer
Author Information
Author(s): Komatsu K, Kobune-Fujiwara Y, Andoh A, Ishiguro S, Hunai H, Suzuki N, Kameyama M, Murata K, Miyoshi J, Akedo H, Tatsuta M, Nakamura H
Primary Institution: Osaka Medical Center for Cancer and Cardiovascular Diseases
Hypothesis
The study investigates the involvement of S100A6 and S100A4 in the malignancy of human colorectal adenocarcinoma.
Conclusion
S100A6 is involved in the invasive process of human colorectal adenocarcinomas, with higher expression levels at the invading fronts compared to central portions.
Supporting Evidence
- In 11 of 12 cases, S100A6 expression levels were higher in tumor tissue than in normal tissue.
- The average S100A6 level in tumor tissue was about 2.3 times higher than in normal tissue.
- S100A6 levels were higher in liver metastasis than in primary tumors in two of three matched samples.
- 55% of primary colorectal adenocarcinoma specimens were positively stained for S100A6.
- 94% of liver metastasis specimens were positively stained for S100A6.
- S100A6 immunostaining was significantly more intense in the invading fronts than in central portions.
Takeaway
This study found that a protein called S100A6 is more present in the parts of colorectal cancer that are spreading, which might help us understand how cancer grows.
Methodology
Protein expression levels of S100A6 and S100A4 were examined in primary colorectal adenocarcinoma and paired adjacent normal colorectal mucosa using Western blot analysis.
Statistical Information
P-Value
0.001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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