Cognitive Occupation-Based Programme for Multiple Sclerosis
Author Information
Author(s): Hynes Sinéad M., Dwyer Christopher P., Alvarez-Iglesias Alberto, Rogers Fionnuala, Joyce Robert A., Oglesby Megan H., Moses Anusha, Bane Eimear, Counihan Timothy J., Charamba Beatrice, COB-MS PPI Advisory Panel
Primary Institution: University of Galway
Hypothesis
The study evaluates the feasibility and preliminary efficacy of the Cognitive Occupation-Based programme (COB-MS) for people with Multiple Sclerosis (MS).
Conclusion
The COB-MS programme is feasible and shows preliminary clinical efficacy for improving cognitive functioning in people with MS.
Supporting Evidence
- The COB-MS intervention was well-accepted by participants and occupational therapists.
- Participants in the COB-MS group showed significant improvement in the primary outcome measure compared to the control group.
- Retention rates were high, with 94% of participants completing the post-intervention assessment.
- Qualitative feedback indicated that participants found the program beneficial for managing cognitive difficulties.
- The study met its progression criteria for feasibility, indicating readiness for a definitive trial.
Takeaway
This study tested a program to help people with Multiple Sclerosis improve their thinking skills and found it to be helpful and easy to use.
Methodology
Participants were randomly assigned to either the COB-MS intervention or a wait-list control group, with assessments conducted at baseline, post-intervention, and follow-ups at 12 weeks and 6 months.
Potential Biases
Potential bias due to the single-blind design and the online delivery of the intervention.
Limitations
The trial was impacted by the COVID-19 pandemic, which required changes to the delivery method and may have affected participant engagement.
Participant Demographics
Participants had a mean age of 48.2 years, with 67.3% female and a variety of MS phenotypes.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 5.6 to 13.4
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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