Comparing Methods to Normalize Electromyography in Respiratory Muscles for ALS and Healthy Individuals
Author Information
Author(s): Lima Thiago Bezerra Wanderley, da Fonseca Jessica Danielle Medeiros, da Silva Ana Aline Marcelino, Vieira Rayane Grayce da Silva, Montemezzo Dayane, Otto-Yáñez Matias, Torres-Castro Rodrigo, Júnior Mário Emílio Teixeira Dourado, Resqueti Vanessa Regiane, Fregonezi Guilherme Augusto de Freitas
Primary Institution: PneumoCardioVascular Lab/Hospital Universitário Onofre Lopes, Universidade Federal do Rio Grande do Norte, Brazil
Hypothesis
In healthy subjects, the MVIC is the best normalization method for inspiratory and expiratory muscles, while in ALS patients, the SNIP is the best normalization method for inspiratory muscles and MVIC for expiratory muscles.
Conclusion
The study found that the MVIC method resulted in greater muscle activity in healthy subjects, while the SNIP maneuver was more effective for inspiratory muscles in ALS patients.
Supporting Evidence
- In healthy subjects, inspiratory muscles showed higher activity during MVIC maneuvers.
- In ALS patients, inspiratory muscles had greater activity during the SNIP maneuver compared to MIP.
- Expiratory muscles in both groups exhibited higher activity during MVICRA compared to MEP.
Takeaway
This study looked at how to best measure muscle activity in people with ALS and healthy individuals, finding that different methods work better for each group.
Methodology
A cross-sectional study comparing different methods of normalizing sEMG signals from respiratory muscles in 67 subjects (50 healthy and 17 with ALS) using various respiratory maneuvers.
Limitations
The study had a smaller sample size for diaphragm muscle analysis and used manual resistance application during MVICs without objective measures.
Participant Demographics
The ALS group had a mean age of 52.11 years, while the healthy group had a mean age of 24.80 years.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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