Study of Anti-Malarial Drug Resistance in Yemen
Author Information
Author(s): Mubjer Reem A, Adeel Ahmed A, Chance Michael L, Hassan Amir A
Primary Institution: Aden University, Yemen
Hypothesis
What are the molecular markers of anti-malarial drug resistance in Lahj Governorate, Yemen?
Conclusion
The study provides baseline data on anti-malarial drug resistance markers in Yemen, indicating high prevalence of certain mutations but poor predictive value for treatment failure.
Supporting Evidence
- 61% of patients experienced treatment failure after 14 days.
- 98% of pre-treatment samples showed the pfcrt T76 mutation.
- 5% of samples had the dhfr Arg-59 mutation, indicating emerging resistance.
Takeaway
This study looked at how well a malaria treatment works in Yemen and found that many patients didn't get better, even though the drug was supposed to help.
Methodology
The study involved a therapeutic efficacy test of chloroquine in 124 patients and molecular analysis of blood samples for resistance markers.
Potential Biases
Potential bias due to the selection of patients who sought treatment at a specific hospital.
Limitations
The study was limited to a specific geographic area and may not represent broader trends in Yemen.
Participant Demographics
Patients aged 1 to 40 years, median age 9.5 years.
Statistical Information
P-Value
0.000
Confidence Interval
95% CI = 52.7-70.9
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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