Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?
2008
Heat Shock Protein 90: Potential Role in Alzheimer's Disease Treatment
publication
Evidence: moderate
Author Information
Author(s): Luo Wenjie, Rodina Anna, Chiosis Gabriela
Primary Institution: The Rockefeller University and Memorial Sloan-Kettering Cancer Center
Hypothesis
Hsp90 may play a role in maintaining pathogenic changes that lead to neurodegenerative diseases like Alzheimer's.
Conclusion
Targeting Hsp90 could provide a more comprehensive approach to treating Alzheimer's disease by addressing multiple pathogenic processes.
Supporting Evidence
- Hsp90 helps maintain the stability of proteins involved in neurodegenerative diseases.
- Inhibition of Hsp90 has shown potential in reducing the aggregation of harmful proteins.
- Targeting Hsp90 may address multiple pathways involved in Alzheimer's disease.
Takeaway
Hsp90 is like a helper that keeps certain bad proteins stable in diseases like Alzheimer's, and stopping it might help fix the problem.
Digital Object Identifier (DOI)
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