Blood flow influences vascular growth during tumour angiogenesis
1999
Blood Flow and Tumor Vessel Growth
Sample size: 1
publication
Evidence: moderate
Author Information
Author(s): Nasu R, Kimura H, Akagi K, Murata T, Tanaka Y
Primary Institution: Department of Radiology, Kansai Medical University
Hypothesis
Blood flow influences vascular growth during tumor angiogenesis.
Conclusion
Increased blood flow may cause vascular enlargement in tumor vessels.
Supporting Evidence
- Vascular growth was observed and recorded on videotape for 6 hours.
- Vessels with high blood flow increased in diameter within a few hours.
- New branches formed from vessels with increased blood flow.
- Vessels without increased blood flow showed no change in diameter.
- Tumor sections were stained to identify endothelial cells.
Takeaway
When blood flows more in tumor vessels, they get bigger and grow new branches, but if there's no blood flow, they stay the same.
Methodology
Mammary adenocarcinoma was implanted into Fisher-344 rats, and vascular growth was observed using transparent chambers and videotaped for analysis.
Participant Demographics
Fisher-344 rats were used in the study.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website