Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss
2001
Proteolysis-Inducing Factor and Weight Loss in Cancer Patients
publication
Author Information
Author(s): Cabal-Manzano R, Bhargava P, Torres-Duarte A, Marshall J, Wainer I W
Primary Institution: Georgetown University Medical Center
Hypothesis
Is proteolysis-inducing factor (PIF) expressed in gastrointestinal cancers and does it correlate with weight loss?
Conclusion
The study found that proteolysis-inducing factor is expressed in tumors of patients with gastrointestinal cancers and is linked to weight loss.
Supporting Evidence
- Proteolysis-inducing factor (PIF) is detectable in the urine of cancer patients experiencing weight loss.
- The study provides the first direct evidence that tumors are the source of PIF in humans.
Takeaway
Cancer patients who are losing weight have a substance called proteolysis-inducing factor in their tumors, which can also be found in their urine.
Digital Object Identifier (DOI)
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