MASS III Trial: Comparing Heart Surgery Techniques
Author Information
Author(s): Whady Hueb, Neuza HM Lopes, Bernard J Gersh, Cláudio C Castro, Felipe S Paulitsch, Sergio A Oliveira, Luis A Dallan, Alexandre C Hueb, Noedir A Stolf, José AF Ramires
Primary Institution: Heart Institute of the University of Sao Paulo, Brazil
Hypothesis
Does coronary surgery with cardiopulmonary bypass differ in effectiveness and safety compared to off-pump surgery in patients with multivessel coronary disease?
Conclusion
The MASS III Trial aims to determine the differences in medical effectiveness, safety, and quality of life between on-pump and off-pump coronary surgery.
Supporting Evidence
- Off-pump surgery has been used since 1967 but gained popularity in the 1990s.
- Randomized trials show small differences in outcomes between off-pump and on-pump surgery.
- Long-term follow-up studies indicate potential inferior outcomes for off-pump surgery.
Takeaway
This study is looking at two ways to do heart surgery to see which one is better for patients with blocked arteries.
Methodology
A single-center, prospective, randomized clinical trial comparing on-pump and off-pump coronary surgery.
Potential Biases
Potential selection bias due to the single-center design and surgeon preference for surgical technique.
Limitations
The study is limited to a single institution, which may affect the generalizability of the results.
Participant Demographics
Patients with stable angina and multivessel coronary artery disease, aged 18 and older.
Statistical Information
P-Value
0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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