Oxidative Stress in Neurodegeneration
Author Information
Author(s): Varsha Shukla, Santosh K. Mishra, Harish C. Pant
Primary Institution: National Institute of Neurological Disorders and Stroke, National Institutes of Health
Hypothesis
It is unclear whether oxidative stress contributes to the onset of neurodegeneration or is a secondary manifestation of the neurodegenerative process.
Conclusion
Oxidative stress plays a significant role in various neurodegenerative diseases, including Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis.
Supporting Evidence
- Oxidative stress is linked to the damage of proteins, lipids, and DNA in cells.
- High levels of oxidative stress can lead to cell death and contribute to diseases.
- Neurodegenerative diseases like Alzheimer's and Parkinson's show increased oxidative damage.
- Oxidative stress affects mitochondrial function, which is crucial for brain health.
- Antioxidants may help mitigate some effects of oxidative stress, but their use is controversial.
Takeaway
Oxidative stress is like a bad guy that can hurt our brain cells, leading to diseases like Alzheimer's and Parkinson's. We need to find ways to protect our brain from it.
Methodology
The paper reviews existing literature on oxidative stress and its role in neurodegenerative diseases.
Limitations
The paper does not provide new experimental data but relies on existing studies.
Digital Object Identifier (DOI)
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