Glutamine-Enriched Peptide Diet Reduces Gastrointestinal Toxicity in Rectal Cancer Patients
Author Information
Author(s): Salas-Salas Bárbara Gabriela, Ferrera-Alayón Laura, Calleja-Fernández Alicia, Chicas-Sett Rodolfo, Nogués-Ramia Eva, Zafra-Martín Juan, Lloret Marta
Primary Institution: University Hospital of Gran Canaria Dr. Negrín
Hypothesis
Does a glutamine-enriched peptide diet reduce gastrointestinal toxicity and treatment interruptions in rectal cancer patients undergoing neoadjuvant treatment?
Conclusion
The glutamine-enriched peptide diet had a protective effect on gastrointestinal toxicity and reduced interruptions of oncologic treatment in patients with colorectal cancer.
Supporting Evidence
- The PD group showed a significant reduction in diarrhea and mucositis compared to the DA group.
- Patients receiving PD had fewer interruptions in their radiotherapy treatment.
- Statistical analysis confirmed the effectiveness of the PD in reducing gastrointestinal toxicity.
Takeaway
Patients with rectal cancer who ate a special diet with glutamine had less stomach problems and could keep getting their cancer treatment without stopping.
Methodology
Prospective cohort study comparing a glutamine-enriched peptide diet with exclusive dietary advice in patients undergoing neoadjuvant chemo-radiotherapy.
Potential Biases
Potential bias due to lack of dietary record and individualization of nutritional support.
Limitations
Dietary records were not collected, and the supplementation pattern was not homogeneous.
Participant Demographics
Adult patients with rectal adenocarcinoma, mostly stage III, with a mean age of approximately 65 years.
Statistical Information
P-Value
0.049
Confidence Interval
95% CI = 0.052–0.923
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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