Diacylglycerol kinase ζ inhibits myocardial atrophy and restores cardiac dysfunction in streptozotocin-induced diabetes mellitus
2008
Diacylglycerol kinase ζ and its role in heart health in diabetes
Sample size: 15
publication
10 minutes
Evidence: high
Author Information
Author(s): Olga Bilim, Yasuchika Takeishi, Tatsuro Kitahara, Takanori Arimoto, Takeshi Niizeki, Toshiki Sasaki, Kaoru Goto, Isao Kubota
Primary Institution: Yamagata University School of Medicine
Hypothesis
DGKζ attenuates changes in cardiac structure and function in response to hyperglycemia.
Conclusion
DGKζ modulates intracellular signaling and improves the course of diabetic cardiomyopathy.
Supporting Evidence
- Diabetic WT mice showed significant heart weight loss compared to control mice.
- DGKζ-TG mice had less cardiac fibrosis than diabetic WT mice.
- Translocation of PKC isoforms was significantly attenuated in DGKζ-TG mice.
Takeaway
This study shows that a special protein called DGKζ helps protect the heart from damage caused by diabetes.
Methodology
Transgenic mice with cardiac-specific overexpression of DGKζ were compared to wild type mice in a diabetic model induced by streptozotocin.
Participant Demographics
8–10 weeks old male mice
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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