FGFR4 Arg388 allele and melanoma progression
Author Information
Author(s): Streit S, Mestel D S, Schmidt M, Ullrich A, Berking C
Primary Institution: Ludwig-Maximilian University of Munich
Hypothesis
The FGFR4 Arg388 allele correlates with tumor thickness and FGFR4 protein expression in melanoma patients.
Conclusion
The Arg388 genotype and FGFR4 protein expression may serve as potential markers for melanoma progression.
Supporting Evidence
- FGFR4 protein was expressed in 45% of melanoma specimens.
- FGFR4 expression correlated with pTNM tumor stages.
- Arg388 allele was significantly associated with tumor thickness.
Takeaway
This study found that a specific gene variant and protein expression are linked to how advanced melanoma is, which could help doctors understand and treat the disease better.
Methodology
The study analyzed FGFR4 protein expression in 137 melanoma tissues and genotyped 185 melanoma patients for the Arg388 allele using PCR-RFLP.
Limitations
The study did not find a correlation between the Arg388 genotype and overall survival rates.
Participant Demographics
The cohort consisted of 93 female and 105 male patients with a median age of 65 years.
Statistical Information
P-Value
P=0.004
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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