Gastroprotective Effect of Ginger Rhizome (Zingiber officinale) Extract: Role of Gallic Acid and Cinnamic Acid in H+, K+-ATPase/H. pylori Inhibition and Anti-Oxidative Mechanism
2011

Ginger Extract's Effect on Stomach Ulcers

Sample size: 30 publication 10 minutes Evidence: high

Author Information

Author(s): Nanjundaiah Siddaraju M., Annaiah Harish Nayaka, Dharmesh Shylaja M.

Primary Institution: Central Food Technological Research Institute, CSIR, Mysore, Karnataka, India

Hypothesis

Can ginger extract prevent stomach ulcers and inhibit harmful bacteria?

Conclusion

Ginger extract significantly protects against stomach ulcers and inhibits the growth of Helicobacter pylori.

Supporting Evidence

  • Ginger extract protected against ulcers by up to 86%.
  • It normalized levels of harmful enzymes in ulcer-induced rats.
  • Ginger extract inhibited the growth of H. pylori.
  • It showed no lethal effects in toxicity studies.
  • Ginger extract improved antioxidant enzyme levels in treated rats.

Takeaway

Ginger can help keep your tummy safe from hurting and bad germs.

Methodology

Rats were treated with ginger extract and then subjected to stress-induced ulcers to assess protective effects.

Potential Biases

Potential bias in the selection of animal models and treatment dosages.

Limitations

The study was conducted on rats, which may not fully represent human responses.

Participant Demographics

Wistar albino rats weighing 180-220g.

Statistical Information

P-Value

0.003

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1093/ecam/nep060

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