Using Dimethyl Fumarate to Treat Obesity Caused by High-Fat Diets
Author Information
Author(s): Valenca Helber da Maia, Mota Evelyn Caribé, Silva Andressa Caetano da Fonseca Andrade, Figueiredo-Junior Alexsandro Tavares, Verdini Fernanda, Romana-Souza Bruna, Renovato-Martins Mariana, Lanzetti Manuella, Valenca Samuel dos Santos, Moraes João Alfredo
Primary Institution: Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ)
Hypothesis
DMF can regulate metabolism in mice subjected to a high fat/high sucrose diet (HFHSD).
Conclusion
DMF and its metabolite MMF interfere with adipogenesis and prevent key features of diet-induced obesity.
Supporting Evidence
- MMF prevented the development of adipogenesis by reducing the expression of transcription factors.
- DMF reduced calorie intake, body weight, and fat mass in HFHSD mice.
- DMF improved glycemic response and reduced leptin and adiponectin plasma levels.
Takeaway
This study shows that a drug called DMF can help mice lose weight and improve their health when they eat a lot of fat and sugar.
Methodology
The study involved in vitro tests on 3T3-L1 preadipocytes and in vivo tests on male C57BL/6 mice fed a high-fat/high-sucrose diet.
Potential Biases
The study did not assess the histology and function of other metabolically relevant organs.
Limitations
The in vitro study used only three MMF concentrations, and the in vivo study was conducted in mice, which may not directly translate to humans.
Participant Demographics
34 male C57BL/6 mice, aged 8 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website