Voriconazole Dosing Adjustments Based on Drug Monitoring
Author Information
Author(s): Jiang Li, Lin Zhiqiang
Primary Institution: Department of Pharmacy, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian Province, China
Hypothesis
Can voriconazole dosing be optimized through therapeutic drug monitoring?
Conclusion
Voriconazole dosing should be individualized based on hepatic function and other factors, with adjustments made according to therapeutic drug monitoring results.
Supporting Evidence
- Therapeutic drug monitoring can help achieve target voriconazole concentrations.
- Adjustments based on monitoring can improve patient outcomes.
- Genetic testing for CYP2C19 is not routinely recommended before dosing.
Takeaway
Doctors can make better decisions about how much voriconazole to give patients by checking their blood levels and adjusting the dose accordingly.
Methodology
Systematic search of PubMed and Embase for studies on voriconazole dose adjustments guided by therapeutic drug monitoring.
Potential Biases
Potential bias due to the inclusion of studies with varying quality and methodologies.
Limitations
The study is limited by the variability in dosing recommendations and the lack of uniform guidelines for dose adjustments.
Participant Demographics
Included studies involved both adult and pediatric populations with varying liver function.
Digital Object Identifier (DOI)
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