Effects of Dioscorea on Anxiety in Ovariectomized Rats
Author Information
Author(s): Ho Ying-Jui, Wang Ching-Fu, Hsu Wen-Yu, Tseng Ting, Hsu Cheng-Chin, Kao Mei-Ding, Tsai Yuan-Feen
Primary Institution: Chung Shan Medical University
Hypothesis
The study investigates the effects of dioscorea on emotional behavior and IL-2 levels in the brain of ovariectomized rats.
Conclusion
Dioscorea treatment reversed OVX-induced anxiety and changes in neuroimmunological function in the cortex.
Supporting Evidence
- Anxiety levels were significantly higher in ovariectomized rats compared to sham-operated rats.
- Dioscorea treatment decreased anxiety and IL-2 levels in high anxiety ovariectomized rats.
- Learned helplessness in the forced swim test was inhibited by the highest dosage of dioscorea.
Takeaway
This study found that a plant called dioscorea can help reduce anxiety in female rats that had their ovaries removed.
Methodology
Female Wistar rats were divided into low and high anxiety groups and treated with dioscorea for 27 days, followed by behavioral tests and IL-2 level measurement.
Limitations
The study's findings may not directly translate to humans due to species differences.
Participant Demographics
Female Wistar rats, aged approximately one month post-ovariectomy.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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