Clot Composition in Stroke Patients with Cancer
Author Information
Author(s): Malin Woock, Rosanna Rossi, Duaa Jabrah, Andrew Douglas, Petra Redfors, Annika Nordanstig, Turgut Tatlisumak, Erik Ceder, Dennis Dunker, Jeanette Carlqvist, István Szikora, Georgios Tsivgoulis, Klearchos Psychogios, Georgios Magoufis, Alexandros Rentzos, Karen M. Doyle, Katarina Jood
Primary Institution: Sahlgrenska University Hospital, University of Galway
Hypothesis
Clots in LVO stroke patients with concomitant cancer differ in composition compared to those in LVO stroke patients without cancer.
Conclusion
Clots from LVO patients with concomitant active cancer have distinct characteristics, indicating an influence of cancer on clot formation.
Supporting Evidence
- Patients with active cancer have a higher risk of ischemic stroke.
- Clots from cancer patients had more von Willebrand factor and citrullinated histone H3.
- The presence of collagen in clots was indicative of active cancer.
- The study included 64 patients with cancer and 64 matched controls.
Takeaway
This study found that blood clots from stroke patients who also have cancer are different from those who don't have cancer, which might help doctors understand how to treat these patients better.
Methodology
The study compared the histological composition of clots from 64 LVO stroke patients with active cancer to 64 matched controls without cancer.
Potential Biases
Only patients with concomitant cancer and LVO stroke accepted for thrombectomy were included, which may not represent all cancer-related stroke patients.
Limitations
The study's sample size was limited, restricting statistical power and not allowing for separate investigation of clots in different types, stages, or treatment of cancer.
Participant Demographics
Mean age of patients with active cancer was 72 years, with 50% being male.
Statistical Information
P-Value
p<0.0001 for vWF, p=0.027 for H3Cit, p=0.002 for collagen presence.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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