Gastrodia Elata Bl Reduces Cocaine Effects in Mice
Author Information
Author(s): Shin E.-J, Bach J.-H, Nguyen T.-T.L, Jung B.-D, Oh K.-W, Kim M. J, Jang C.G, Ali S.F, Ko S.K, Yang C.H, Kim H.-C
Primary Institution: Kangwon National University
Hypothesis
Does Gastrodia elata Bl affect cocaine-induced seizures, conditioned place preference, and behavioral sensitization in mice?
Conclusion
Gastrodia elata Bl reduces cocaine-induced seizures and conditioned place preference through GABAA receptor activation.
Supporting Evidence
- GE significantly delayed seizure onset and shortened seizure duration induced by cocaine.
- GE attenuated cocaine-induced conditioned place preference in a dose-dependent manner.
- GE did not significantly alter behavioral sensitization induced by cocaine.
Takeaway
Gastrodia elata Bl helps mice not feel the effects of cocaine as much, especially when it comes to seizures and preferences for places associated with cocaine.
Methodology
Mice were treated with Gastrodia elata and cocaine, and their seizure onset, duration, and conditioned place preference were measured.
Limitations
The study only used male C57BL/6J mice, which may limit the generalizability of the findings.
Participant Demographics
Male C57BL/6J mice, weighing 25 ± 3 g.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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