An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study
2012

GutGard for Functional Dyspepsia

Sample size: 50 publication 10 minutes Evidence: high

Author Information

Author(s): Raveendra Kadur Ramamurthy, Jayachandra, Srinivasa Venkatappa, Sushma Kadur Raveendra, Allan Joseph Joshua, Goudar Krishnagouda Shankargouda, Shivaprasad Hebbani Nagarajappa, Venkateshwarlu Kudiganti, Geetharani Periasamy, Sushma Gopalakrishna, Agarwal Amit

Primary Institution: Srinivasa Diabetic Research Centre, Bangalore, India

Hypothesis

GutGard, an extract of Glycyrrhiza glabra, is effective in alleviating symptoms of functional dyspepsia.

Conclusion

GutGard significantly reduces symptoms of functional dyspepsia and improves quality of life compared to placebo.

Supporting Evidence

  • GutGard showed a significant decrease in total symptom scores on day 15 and day 30 compared to placebo.
  • 14 patients in the GutGard group reported marked improvement in symptoms, while none in the placebo group did.
  • GutGard resulted in a significant decrease in the Nepean dyspepsia index on day 15 and day 30.

Takeaway

This study shows that a special licorice extract can help people with tummy troubles feel better.

Methodology

A randomized, double-blind, placebo-controlled study with 50 patients receiving either GutGard or placebo for 30 days.

Potential Biases

Potential bias in self-reported symptom scores.

Limitations

The study was limited to a specific population and may not be generalizable to all patients with functional dyspepsia.

Participant Demographics

50 patients, 25 in each group, with a mix of males and females.

Statistical Information

P-Value

p ≤ 0.05

Statistical Significance

p ≤ 0.05

Digital Object Identifier (DOI)

10.1155/2012/216970

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