Genetic Variations in Antioxidant Enzymes and Cataract Risk
Author Information
Author(s): Zhang Yi, Zhang Lan, Sun DongLin, Li ZhiSheng, Wang Lin, Liu Ping
Primary Institution: Harbin Medical University
Hypothesis
Polymorphic variations in antioxidant genes modify the risk of age-related cataract.
Conclusion
The G/G genotype of the SOD1β251A/G polymorphism may be associated with an increased risk of cataract.
Supporting Evidence
- SOD1 G/G genotype frequency was significantly higher in cataract patients.
- SOD1 A/A genotypes seem to have a protective role against cataract.
- No significant differences were found in CATβ21A/T and GPX1β198C/T polymorphisms.
Takeaway
This study looked at how certain genes related to antioxidants might affect the risk of getting cataracts as we age. They found that one specific gene variant could increase the risk.
Methodology
The study included 415 cataract patients and 386 healthy controls, with genotyping performed using PCR-RFLP methods.
Limitations
The study focused only on a specific population and may not be generalizable to other ethnic groups.
Participant Demographics
415 cataract patients and 386 healthy controls, all Han Chinese.
Statistical Information
P-Value
p=0.001
Confidence Interval
95% CI=1.129β2.389
Statistical Significance
p<0.05
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