Vitamin D Binding Protein Variants and Asthma in Chinese Han Population
Author Information
Author(s): Li Fei, Jiang Lei, Willis-Owen Saffron A, Zhang Youming, Gao Jinming
Primary Institution: Peking Union Medical College Hospital
Hypothesis
Are polymorphisms of genes encoding for vitamin D receptor, vitamin D 25-hydroxylase, and vitamin D binding protein associated with asthma in the Chinese Han population?
Conclusion
Variants in the GC gene are associated with asthma susceptibility in the Chinese Han population.
Supporting Evidence
- The study included 467 asthma patients and 288 healthy controls.
- Variants in the GC gene were significantly associated with asthma susceptibility.
- No significant association was found for VDR and CYP2R1 variants.
Takeaway
This study found that certain genetic variations related to vitamin D are linked to asthma risk in Chinese people.
Methodology
The study sequenced exons of VDR and CYP2R1 in a case-control cohort of asthma patients and healthy controls, genotyping specific SNPs.
Limitations
The study did not find associations between VDR and CYP2R1 variants and asthma, suggesting potential limitations in the genetic markers studied.
Participant Demographics
467 asthma patients and 288 unrelated healthy controls, predominantly Han ethnicity.
Statistical Information
P-Value
0.006
Confidence Interval
95% CI = 1.01-1.78
Statistical Significance
p = 0.006
Digital Object Identifier (DOI)
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