Uncoiling Mechanics of E. coli Type I Fimbriae Are Optimized for Catch Bonds
2006
How E. coli Fimbriae Help Bacteria Stick
publication
Evidence: moderate
Author Information
Author(s): Manu Forero, Evgeni Sokurenko, Viola Vogel
Hypothesis
Do the coiled rod structures of fimbriae affect the binding of FimH to mannose?
Conclusion
The study shows that the mechanical properties of fimbriae enhance the stability of the FimH-mannose bond under varying fluid conditions.
Supporting Evidence
- The fimbriae stretch out under force, improving the binding of FimH.
- Individual pilin subunits uncoil one at a time, contributing to fimbrial elongation.
- Fimbriae re-coil under low force, maintaining optimal tension for bond stability.
Takeaway
E. coli bacteria have tiny hair-like structures that help them stick better to surfaces when there is fluid flow, like in our bodies.
Methodology
The researchers used an atomic force microscope to measure the forces between fimbriae and mannose.
Digital Object Identifier (DOI)
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