Capsular Serotype and Antibiotic Resistance of Streptococcus pneumoniae Isolates in Malaysia
Author Information
Author(s): Le Cheng-Foh, Palanisamy Navindra Kumari, Mohd Yusof Mohd Yasim, Sekaran Shamala Devi
Primary Institution: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Hypothesis
The study investigates the serotype distribution of pneumococcal isolates to predict the efficacy of the 7-valent pneumococcal conjugate vaccine (PCV7) among the Malaysian populations.
Conclusion
The study revealed that several serotypes associated with high penicillin resistance are included in the PCV7, suggesting that its use could be beneficial for the Malaysian population.
Supporting Evidence
- 21.2% of isolates were penicillin-resistant.
- Serotype 19F was the most prevalent, accounting for 37.1% of isolates.
- High prevalence of pneumococcal isolates was detected among children under 5 years old.
Takeaway
Researchers looked at different types of bacteria that cause pneumonia in Malaysia to see how well a vaccine works against them.
Methodology
A total of 151 clinical isolates were serotyped using multiplex PCR assays to determine their penicillin susceptibility.
Limitations
The study is based on a single center and may not represent the entire Malaysian population.
Participant Demographics
The isolates were obtained from both pediatric and adult patients, with a focus on children under 5 years old and elderly adults over 60.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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