Ceruloplasmin Levels and Obsessive Compulsive Disorder
Author Information
Author(s): Virit Osman, Selek Salih, Bulut Mahmut, Savas Haluk Asuman, Celik Hakim, Erel Ozcan, Herken Hasan
Primary Institution: Gaziantep University
Hypothesis
Is there an association between ceruloplasmin levels and obsessive-compulsive disorder (OCD)?
Conclusion
There was an association between ceruloplasmin levels and OCD, although the nature of the relationship is not clear.
Supporting Evidence
- The mean ceruloplasmin level in pure OCD patients was significantly higher than in the control group.
- Positive predictive value of ceruloplasmin for the cut-off point was 100%.
- Negative predictive value was 91% in the study group.
Takeaway
This study found that people with OCD have higher levels of a protein called ceruloplasmin in their blood compared to healthy people.
Methodology
The study included 26 pure OCD patients, 9 co-morbid OCD patients, and 40 healthy controls, with blood samples collected to measure ceruloplasmin levels.
Potential Biases
Potential bias due to the small sample size and the inclusion of patients with comorbid psychiatric disorders.
Limitations
The sample size is relatively small, not all patients had pure OCD, and all patients were receiving drug therapy.
Participant Demographics
37 OCD patients (30 females, 7 males) and 40 healthy controls (30 females, 10 males).
Statistical Information
P-Value
< 0.001
Confidence Interval
0.971 to 1.006
Statistical Significance
p < 0.01
Digital Object Identifier (DOI)
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