Behavior and Function of Dendritic Cells in the Inflamed Brain during Toxoplasmic Encephalitis
Author Information
Author(s): John Beena, Ricart Brendon, Tait Wojno Elia D., Harris Tajie H., Randall Louise M., Christian David A., Gregg Beth, De Almeida Daniel Manzoni, Weninger Wolfgang, Hammer Daniel A., Hunter Christopher A.
Primary Institution: University of Pennsylvania
Hypothesis
What are the behaviors and functions of dendritic cells in the brain during toxoplasmic encephalitis?
Conclusion
The study reveals that dendritic cells in the brain during toxoplasmic encephalitis exhibit distinct behaviors and are capable of presenting antigens to T cells.
Supporting Evidence
- Dendritic cells in the brain during toxoplasmic encephalitis form an extensive network and exhibit distinct morphologies.
- CD11c+ cells in the brain can present antigens to T cells and are primarily bone marrow-derived.
- The migration of dendritic cells into the brain is dependent on the integrin LFA-1 and is sensitive to pertussis toxin.
Takeaway
Dendritic cells in the brain change how they act during a Toxoplasma infection, helping to fight the infection by interacting with T cells.
Methodology
The study used real-time imaging, transgenic reporter mice, and recombinant parasites to analyze dendritic cells in the brain during infection.
Limitations
The study does not clarify whether dendritic cells in the brain are constantly renewed or recruited from peripheral circulation.
Digital Object Identifier (DOI)
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