IgG Subclass Shift as a Marker for Head and Neck Cancer
Author Information
Author(s): Anderhuber W, Steinschifter W, Schauenstein E, Gotschuli A, Habermann W, Fischer M, Felsner P, Schauenstein K
Primary Institution: Department of Otolaryngology, University of Graz
Hypothesis
Is the IgG1/G2 subclass shift observed in patients with squamous cell carcinoma of the head and neck, and what is its diagnostic performance?
Conclusion
The decrease in %IgG1 and increase in %IgG2 is an effective marker for detecting squamous cell carcinoma of the head and neck, especially useful for post-therapeutic monitoring.
Supporting Evidence
- 105 SCC-HN patients had a mean value of 56.0% IgG1, significantly different from healthy controls and benign diseases.
- Sensitivities and specificities for discriminating primary malignancies from healthy controls were 70% and 74%, respectively.
- Post-therapeutic cases with tumor recurrence showed 88% sensitivity and 75% specificity.
Takeaway
Doctors can check the levels of certain antibodies in the blood to help find and monitor throat cancer.
Methodology
Serum concentrations of IgG1, IgG2, and total IgG were measured using quantitative affinity chromatography in patients with squamous cell carcinoma and compared to healthy controls.
Participant Demographics
81 patients with primary untreated SCC-HN, 51 post-therapeutic SCC-HN patients, and 33 patients with benign diseases.
Statistical Information
P-Value
<0.0005
Statistical Significance
p<0.0005
Digital Object Identifier (DOI)
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