CD44 Expression and Prognosis in Gastrointestinal Lymphoma
Author Information
Author(s): H. Joensuu, R. Ristamaki, P.J. Klemi, S. Jalkanen
Primary Institution: Turku University Central Hospital
Hypothesis
Lymphocyte homing receptor (CD44) expression is associated with poor prognosis in gastrointestinal lymphoma.
Conclusion
Lack of lymphocyte homing receptor expression is common in gastrointestinal lymphoma, and CD44 expression is associated with unfavorable prognosis.
Supporting Evidence
- Lymphomas lacking or with very weak homing receptor expression had a 57% 10-year survival rate.
- Only 15% of lymphomas with strong CD44 expression were alive 10 years after diagnosis.
- The study suggests that CD44 expression may be one of the strongest prognostic factors in gastrointestinal lymphoma.
Takeaway
This study found that patients with gastrointestinal lymphoma who have low levels of a specific protein called CD44 tend to live longer than those with high levels of it.
Methodology
The study analyzed 27 patients with gastrointestinal lymphoma, assessing CD44 expression through immunohistochemistry and following their survival for 8 to 20 years.
Limitations
The study had a small sample size and did not perform multivariate analysis due to this limitation.
Participant Demographics
63% of participants were male, with a median age of 65 years.
Statistical Information
P-Value
0.02
Statistical Significance
p=0.02
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