(S)-2-(1-MethylÂindolin-2-yl)-1,3-diphenylÂpropan-2-ol
2011
Study of a New Organic Compound
publication
Evidence: moderate
Author Information
Author(s): Lin Ning, Chen Miao-Miao, Deng Yan-Qiu, Luo Ren-Shi, Ng Seik Weng
Primary Institution: School of Pharmaceutical Sciences, Sun Yat-sen University
Hypothesis
The new compound is expected to have enhanced pharmaceutical properties compared to its precursor.
Conclusion
The compound was synthesized successfully with nearly quantitative yield.
Supporting Evidence
- The new compound was synthesized with nearly quantitative yield.
- The five-membered ring in the molecule is almost planar.
- The tertiary nitrogen atom shows a flattened pyramidal configuration.
Takeaway
Scientists made a new chemical compound that might work better as a medicine than an older one.
Methodology
The compound was synthesized using a Grignard reaction and purified by column chromatography.
Digital Object Identifier (DOI)
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