The metastasis associated protein S100A4: role in tumour progression and metastasis
2005
The Role of S100A4 in Cancer Progression
publication
Evidence: moderate
Author Information
Author(s): Helfman D M, Kim E J, Lukanidin E, Grigorian M
Primary Institution: University of Miami School of Medicine
Hypothesis
S100A4 is a potential molecular marker for metastatic potential in tumors.
Conclusion
S100A4 is associated with worse prognosis in various cancers, particularly breast cancer.
Supporting Evidence
- S100A4-positive tumors have a significantly worse survival rate compared to S100A4-negative tumors.
- Studies show S100A4 is a significant marker of prognosis in early-stage breast cancer.
- Extracellular S100A4 influences tumor progression by affecting cell motility and invasion.
Takeaway
S100A4 is a protein that helps cancer cells spread, and knowing its levels can help doctors understand how serious the cancer is.
Methodology
The review discusses biochemical properties and cellular functions of S100A4 in metastasis.
Limitations
The role of S100A4 as a prognostic factor remains uncertain due to conflicting study results.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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