Impact of Non-HDL Cholesterol on Heart Disease in Saudis
Author Information
Author(s): Nasser M Al-Daghri, Omar S Al-Attas, Khalid Al-Rubeaan
Primary Institution: King Saud University
Hypothesis
This study aims to determine and compare the impact of non-HDL-C versus other lipid parameters in predicting coronary heart disease among diabetic versus non-diabetic adult Saudis.
Conclusion
This study supports the use of non-HDL cholesterol as the more practical and reliable target for lipid lowering therapy among the Saudi population.
Supporting Evidence
- Non-HDL cholesterol was the best predictor among non-diabetics.
- 21.3% of non-diabetics had coronary heart disease compared to 52.5% of diabetics.
- Elevated triglycerides were a significant contributor to coronary heart disease.
Takeaway
This study found that non-HDL cholesterol is better at predicting heart disease than other types of cholesterol in Saudis, especially in non-diabetics.
Methodology
733 adult Saudis were recruited, divided into diabetic and non-diabetic groups, and underwent physical exams and blood tests to analyze lipid parameters.
Potential Biases
The unequal distribution of non-diabetics and diabetics may have influenced the results.
Limitations
The study did not control for confounding factors such as smoking, hypertension, obesity, gender, and family history.
Participant Demographics
462 non-diabetics (average age 45.03) and 271 diabetics (average age 52.73) were included.
Statistical Information
P-Value
0.03
Confidence Interval
1.10–7.58
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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