Factors Influencing Growth Hormone and IGF Levels in Young Adults with Pituitary Stalk Interruption Syndrome
Author Information
Author(s): Marcu Mariana, Trivin Christine, Souberbielle Jean-Claude, Brauner Raja
Primary Institution: Université Paris Descartes and Assistance Publique Hôpitaux de Paris
Hypothesis
What factors influence the growth hormone peak and plasma insulin-like growth factor I in young adults with pituitary stalk interruption syndrome?
Conclusion
The growth hormone peak response and plasma IGF I concentration in young adults with growth hormone deficiency depend on the presence of additional pituitary deficiencies.
Supporting Evidence
- Group 1 had a greater pituitary height and GH peak than group 2 at diagnosis.
- At last evaluation, group 1 had greater GH peak and plasma IGF I than group 2.
- The GH peak decreased between diagnosis and last evaluation only in group 2.
Takeaway
This study looked at young adults with a condition that affects their growth hormone levels and found that having other hormone deficiencies makes their growth hormone problems worse.
Methodology
Retrospective longitudinal study comparing GH peaks and plasma IGF I concentrations in two groups of patients with isolated GHD and multiple pituitary deficiencies.
Limitations
The number of subjects studied is limited, and the GH peaks were not obtained using similar stimulations.
Participant Demographics
21 patients (13 boys and 8 girls) with GHD of prepubertal onset due to PSIS.
Statistical Information
P-Value
P < 0.008
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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