Zangrado: A New Treatment for Nausea and Itch
Author Information
Author(s): Miller Mark JS, Reuter Brian K, Wallace John L, Sharkey Keith A
Primary Institution: Center for Cardiovascular Sciences, Albany Medical College
Hypothesis
Can Zangrado, a Croton palanostigma extract, effectively manage emesis and itch without common side effects?
Conclusion
Zangrado is an effective anti-emetic and anti-itch therapy that does not cause sedation or hypothermia.
Supporting Evidence
- Zangrado reduced morphine-induced vomiting by 77%.
- It blocked itch responses in both morphine and serotonin models.
- Zangrado did not cause sedation or hypothermia in treated ferrets.
- It showed a tendency to improve weight gain in ApcMin mice.
- Zangrado suppressed nitrite production in activated macrophages.
Takeaway
Zangrado is a natural remedy that helps stop vomiting and itching without making you sleepy or cold.
Methodology
The study involved inducing emesis in ferrets and assessing the effects of Zangrado on vomiting, itch, and polyp development in mice.
Potential Biases
Potential bias due to the proprietary nature of the Zangrado extract and the involvement of the authors with the supplier.
Limitations
The results regarding weight gain and polyp number in mice did not reach statistical significance.
Participant Demographics
Adult ferrets and male Sprague Dawley rats were used in the experiments.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website